Laurie H. Sehn , Laurie H. Gianpietro Semenzato , Gianpietro Semenzato. Louis M. Staudt , Louis M. Steven H. Swerdlow , Steven H. Constantine S. Tam , Constantine S. Judith Trotman , Judith Trotman.

Julie M. Vose , Julie M. Oliver Weigert , Oliver Weigert. Wyndham H. Wilson , Wyndham H. Jane N. Winter , Jane N. Catherine J. Wu , Catherine J. Pier L. Zinzani , Pier L. Emanuele Zucca , Emanuele Zucca. Adam Bagg , Adam Bagg. David W. Scott David W. Blood 21 : — Article history Submitted:. Connected Content.

This is a related article to: The International Consensus Classification of Mature Lymphoid Neoplasms: a report from the Clinical Advisory Committee. This is a related article to: International Consensus Classification of Myeloid Neoplasms and Acute Leukemias: integrating morphologic, clinical, and genomic data.

This is a related article to: Developing a classification of hematologic neoplasms in the era of precision medicine. View more. A related article has been published: Genomic profiling for clinical decision making in myeloid neoplasms and acute leukemia.

View less. Split-Screen Share Icon Share Facebook Twitter LinkedIn MailTo Tools Icon Tools Request Permissions. Cite Icon Cite. toolbar search Search Dropdown Menu. toolbar search search input Search input auto suggest. Figure 1. View large Download PPT. Table 1. Clinical impact of genomic testing in B-cell neoplasms. Genetic alteration: test. Diagnostic use. Clinical impact. Future assays. View Large. Table 2. Clinical impact of genomic testing in T-cell neoplasms.

CCR4 mutations predictive of response to mogamulizumab. Table 3. Utility of genomic testing in selected diagnostic settings.

Diagnostic scenario. Genomic testing. Overlapping and heterogeneous mutational landscapes; mutations in the following genes have the most discriminant value: KLF2 , NOTCH2 , PTPRD , CARD11 , IRF8 , MAP2K1 favor MZLs and pediatric-type MZL ; CREBBP , EZH2 , TNFRSF14 in FLs , STAT6 favor BCL2-R —negative, CDpositive follicle center lymphoma ; BRAF in virtually all hairy cell leukemias, also in some MZLs 1C: Cutaneous involvement by follicular B-cell lymphoma: primary cutaneous follicle center lymphoma; systemic FL Demonstration of BCL2 rearrangement favors systemic FL but does not exclude primary cutaneous follicle center lymphoma.

Mutational landscapes overlap with less frequent incidence of mutations in BCL2 , CREBBP , EP , EZH2 , KMT2D more frequent mutations in TNFAIP3 , and similar occurrences of TNFRSF14 mutations or 1p36 deletions in primary cutaneous vs systemic cases Scenario 2: B-cell neoplasms with plasmacytic differentiation and plasma cell neoplasms 2A: Small B-cell lymphoma with plasmacytic differentiation: LPL; nodal MZLs; splenic MZL; extranodal MZL MALT lymphoma ; FL Demonstration of BCL2 rearrangement supports the diagnosis of FL.

Demonstration of trisomies of chromosomes 3 and 18 or del 7q supports the diagnosis of MZL. Translocations of MALT1 , FOXP1 , and BCL10 are specific for MALT lymphomas.

MYD88 LP mutation is highly suggestive of LPL but not entirely specific because it is also found in a subset of other small B-cell lymphomas. Coexisting CXCR4 mutation further increases the specificity for LPL. Overlapping and heterogeneous mutational landscapes; mutations in the following genes have the most discriminant value: MYD88 and CXCR4 favor LPL ; BRAF , KLF2 , NOTCH2 , PTPRD , TNFAIP3 favor MZLs ; CREBBP , EZH2 , TNFRSF14 favor FL 2B: Bone marrow with IgM-secreting neoplasm: IgM MGUS, plasma cell type; IgM MGUS, NOS; LPL; IgM plasmacytoma; IgM plasma cell myeloma Demonstration of translocations of CCND or MAF family genes or NSD2 indicates a plasma cell neoplasm.

Mutational landscapes are distinct with MYD88 LP mutation present in most LPL and MGUS, NOS; other discriminant mutations involve ARID1A , CD79B , CXCR4 , KMT2D in lymphoplasmacytic neoplasms and BRAF , DIS3 , KRAS , NRAS , TENT5C , and TRAF3 in plasma cell neoplasms. Genomic testing does not resolve the differential diagnosis of MGUS vs lymphoma or myeloma 2C: Small B-cell lymphoma, with spleen, bone marrow, or blood involvement: splenic MZL; hairy cell leukemia; splenic diffuse red pulp small B-cell lymphoma; hairy cell leukemia variant; MCL Demonstration of CCND1 rearrangement establishes the diagnosis of MCL.

Detection of del 7q is not discriminant in this context. Mutational landscapes are distinct with BRAF VE mutation being a highly diagnostically sensitive marker for hairy cell leukemia, although not entirely specific; other mutations supportive of diagnosis in this context include MAP2K1 mutations favor hairy cell leukemia variant ; those in KLF2 and NOTCH2 favor splenic MZL ; and those in BCOR and CCND3 favor splenic diffuse red pulp small B-cell lymphoma 2D: EBV-negative plasmablastic neoplasm: plasmablastic lymphoma; plasmablastic MM; ALK-positive DLBCL Demonstration of translocations of CCND or MAF families or NSD2 indicates an MM; ALK translocations generally substituted by IHC define ALK-positive DLBCL.

Demonstration of MYC rearrangement while supporting the diagnosis of plasmablastic lymphoma does not exclude plasmablastic MM. Overlapping and heterogeneous mutational landscapes; mutations in the following genes more frequent in plasmablastic lymphoma: EP , MYC , SOCS1 , STAT3 , TET2 , and TP53 Scenario 3: LBCLs 3A: Nodal-based follicular B-cell lymphoproliferations with a predominance of large cells in the pediatric population: pediatric-type FL; follicular hyperplasia; LBCL- IRF4 rearrangement; in adults: FL grade 3A; FL grade 3B; LBCL- IRF4 rearrangement Demonstration of monoclonal IG gene rearrangement is useful to establish the diagnosis of lymphoma over reactive hyperplasia, in particular in pediatric conditions.

Demonstration of BCL2 rearrangement favors grade 3A over grade 3B FL and excludes pediatric entities. BCL6 rearrangement occurs in both grade 3A and 3B cases, more commonly in 3B, but not in pediatric-type FL Demonstration of IRF4 or IGH, IGK or IGL rearrangements is essential for supporting LBCL- IRF4 rearrangement; demonstration of one or several IRF4 mutations in exon is a strong indicator of IRF4 rearrangement including cryptic translocation.

IRF4 rearrangement can be present in association with other rearrangement s BCL2 or MYC in DLBCLs, and these do not qualify for LBCL- IRF4. Mutations in ID3 and TCF3 favor BL whereas B2M , CREBBP , EZH2 , MYD88 LP , SOCS1 , and TNFRSF14 mutations favor other aggressive B-cell entities. Similarly, BCL2 mutations imply the presence of IGH:: BCL2 , thereby favoring entities other than BL 3C: LBCL involving mediastinum: PMBCL; DLBCL, NOS involving mediastinum; mediastinal gray-zone lymphoma Demonstration of BCL2 or BCL6 rearrangement favors DLBCL, NOS, as these uncommonly occur in PMBCL; conversely, CIITA rearrangement, CD rearrangement or CNV are typical of primary mediastinal lymphomas.

Mutations in IL4R , ITPKB , NFKBIE , SOCS1 , STAT6 , and XPO1 are characteristic of PMBCL, while several genes often mutated in DLBCL, NOS, such as CD79B , CREBBP , KMT2D , MYD88 , PIM1 , and others, are not altered in PMBCL. Mediastinal gray-zone lymphoma has genomic features closer to PMBCL than to DLBCL, NOS, but distinctive genomic features between mediastinal gray-zone lymphoma and PMBCL are not described. Gene expression—based tests differentiate PMBCL from DLBCL, NOS 3D: Cyclin D1—positive blastoid or pleomorphic B-cell neoplasm: MCL; DLBCL, NOS positive for cyclin D1 expression; DLBCL, NOS with CCND1 rearrangement Demonstration of CCND1 translocation indicates MCL or DLBCL with CCND1 rearrangement.

Demonstration of additional BCL2 , BCL6 , or MYC rearrangement is common in DLBCL with CCND1 translocation. Blastoid MCL may harbor secondary MYC rearrangement or TP53 mutations. Isochromosome 7q is characteristic of HSTCL. T-cell or NK-cell lymphoproliferations are further supported by somatic mutations or fusions STAT3 , JAK3 , JAK2 :: STAT3 , others.

Most discriminant mutated genes between EATL and MEITL are JAK1 and STAT3 more commonly mutated in EATL and GNAI2 , JAK3 , SETD2 , and STAT5B more commonly mutated in MEITL 4E: Lymphoproliferations of large CD positive T cells: ALCL, ALK-positive; ALCL, ALK-negative; BIA-ALCL; PTCL, NOS; primary cutaneous CDpositive lymphoproliferative disorders; transformed mycosis fungoides; subsets of EATL, or ENKTCL Demonstration of ALK rearrangement generally substituted by IHC defines ALCL, ALK-positive.

Demonstration of DUSP22 rearrangement in ALK-negative CDpositive large-cell lymphoproliferations establishes the diagnosis of ALCL, ALK-negative, over PTCL, NOS, but does not discriminate between primary cutaneous vs systemic ALCL, ALK-negative.

VAV1 and TP63 rearrangements occur in small subsets of ALCL, ALK-negative but are not specific for that entity. Demonstration of ALK , DUSP22 , or TP63 translocations exclude BIA cases, whereas chromosome 20q loss is characteristic of that entity. Analysis of somatic mutations provides information on linear vs divergent evolution and secondary genomic alterations.

Figure 2. Figure 3. Figure 4. Figure 5. Figure 6. Laura Hilton contributed to the production of figures. In: Swerdlow. WHO Classification of Tumours of the Haematopoietic and Lymphoid Tissues. Revised 4th ed. The international consensus classification of mature lymphoid neoplasms: a report from the Clinical Advisory Committee. Search ADS. Characteristic chromosomal abnormalities in biopsies and lymphoid-cell lines from patients with Burkitt and non-Burkitt lymphomas.

van den Brand. Next-generation sequencing-based clonality assessment of Ig gene rearrangements: a multicenter validation study by EuroClonality-NGS.

Genetic landscape and deregulated pathways in B-cell lymphoid malignancies. Genetics and prognostication in splenic marginal zone lymphoma: revelations from deep sequencing. Evolution and impact of subclonal mutations in chronic lymphocytic leukemia.

Mutational and structural analysis of diffuse large B-cell lymphoma using whole-genome sequencing. Clinical impact of recurrently mutated genes on lymphoma diagnostics: state-of-the-art and beyond.

Precision diagnostics in lymphomas — recent developments and future directions. Targeted massively parallel sequencing of mature lymphoid neoplasms: assessment of empirical application and diagnostic utility in routine clinical practice. Targeted next-generation sequencing in chronic lymphocytic leukemia: a high-throughput yet tailored approach will facilitate implementation in a clinical setting. High-throughput sequencing for noninvasive disease detection in hematologic malignancies.

Validation of the EuroClonality-NGS DNA capture panel as an integrated genomic tool for lymphoproliferative disorders. Lymphoid NeXt-generation sequencing LYNX panel: a comprehensive capture-based sequencing tool for the analysis of prognostic and predictive markers in lymphoid malignancies.

Distinct biological subtypes and patterns of genome evolution in lymphoma revealed by circulating tumor DNA. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling.

The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma. Epigenomic analysis detects widespread gene-body DNA hypomethylation in chronic lymphocytic leukemia.

DNA methylation dynamics during B cell maturation underlie a continuum of disease phenotypes in chronic lymphocytic leukemia. Double-hit gene expression signature defines a distinct subgroup of germinal center B-cell-like diffuse large B-cell lymphoma.

Prognostic significance of diffuse large B-cell lymphoma cell of origin determined by digital gene expression in formalin-fixed paraffin-embedded tissue biopsies. Simultaneous identification of cell of origin, translocations, and hotspot mutations in diffuse large B-cell lymphoma using a single RNA-sequencing assay. Transcriptome sequencing of archived lymphoma specimens is feasible and clinically relevant using exome capture technology. The landscape of tumor cell states and ecosystems in diffuse large B cell lymphoma.

Single-cell transcriptome analysis reveals disease-defining T-cell subsets in the tumor microenvironment of classic Hodgkin lymphoma. Standards and guidelines for the interpretation and reporting of sequence variants in cancer: a joint consensus recommendation of the Association for Molecular Pathology, American Society of Clinical Oncology, and College of American Pathologists.

A framework to rank genomic alterations as targets for cancer precision medicine: the ESMO Scale for Clinical Actionability of molecular Targets ESCAT. Standards for the classification of pathogenicity of somatic variants in cancer oncogenicity : joint recommendations of Clinical Genome Resource ClinGen , Cancer Genomics Consortium CGC , and Variant Interpretation for Cancer Consortium VICC.

Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia. Unmutated Ig VH genes are associated with a more aggressive form of chronic lymphocytic leukemia. Immunoglobulin gene sequence analysis in chronic lymphocytic leukemia: the update of the recommendations by ERIC, the European Research Initiative on CLL.

Ibrutinib regimens Versus chemoimmunotherapy in older patients with untreated CLL. Venetoclax and obinutuzumab in patients with CLL and coexisting conditions. Ibrutinib plus obinutuzumab versus chlorambucil plus obinutuzumab in first-line treatment of chronic lymphocytic leukaemia iLLUMINATE : a multicentre, randomised, open-label, phase 3 trial. Ibrutinib—rituximab or chemoimmunotherapy for chronic lymphocytic leukemia. Venetoclax plus obinutuzumab versus chlorambucil plus obinutuzumab for previously untreated chronic lymphocytic leukaemia CLL14 : follow-up results from a multicentre, open-label, randomised, phase 3 trial.

Relevance of stereotyped B-cell receptors in the context of the molecular, cytogenetic and clinical features of chronic lymphocytic leukemia. Stereotyped B-cell receptors in one-third of chronic lymphocytic leukemia: a molecular classification with implications for targeted therapies.

ten Hacken. The importance of B cell receptor isotypes and stereotypes in chronic lymphocytic leukemia. Higher-order connections between stereotyped subsets: implications for improved patient classification in CLL. Complex karyotype in unfit patients with CLL treated with ibrutinib and rituximab: the GIMEMA LLC phase 2 study. Genomic variation by whole-genome SNP mapping arrays predicts time-to-event outcome in patients with chronic lymphocytic leukemia: a comparison of CLL and HapMap genotypes.

Cytogenetic complexity in chronic lymphocytic leukemia: definitions, associations, and clinical impact. IGLVR identifies an aggressive biological subtype of chronic lymphocytic leukemia with intermediate epigenetics. Chronic lymphocytic leukemia: molecular heterogeneity revealed by high-throughput genomics. TP53 mutations with low variant allele frequency predict short survival in chronic lymphocytic leukemia.

Clinical impact of small TP53 mutated subclones in chronic lymphocytic leukemia. Mutations in the ATM gene lead to impaired overall and treatment-free survival that is independent of IGVH mutation status in patients with B-CLL.

Resistance mutations to BTK inhibitors originate from the NF-κB but not from the PI3K-RAS-MAPK arm of the B cell receptor signaling pathway. Mechanisms of intrinsic and acquired resistance to venetoclax in B-cell lymphoproliferative disease.

Epigenetic deregulation in chronic lymphocytic leukemia: clinical and biological impact. Del Giudice. Minimal residual disease assessment in CLL: ready for use in clinical routine? Measurable residual disease in chronic lymphocytic leukemia: expert review and consensus recommendations.

Somatic mutations altering EZH2 Tyr in follicular and diffuse large B-cell lymphomas of germinal-center origin. Acquired TNFRSF14 mutations in follicular lymphoma are associated with worse prognosis.

Loss of the HVEM tumor suppressor in lymphoma and restoration by modified CAR-T cells. Acquisition of potential N-glycosylation sites in the immunoglobulin variable region by somatic mutation is a distinctive feature of follicular lymphoma. Integration of gene mutations in risk prognostication for patients receiving first-line immunochemotherapy for follicular lymphoma: a retrospective analysis of a prospective clinical trial and validation in a population-based registry. A gene-expression profiling score for prediction of outcome in patients with follicular lymphoma: a retrospective training and validation analysis in three international cohorts.

Tazemetostat for patients with relapsed or refractory follicular lymphoma: an open-label, single-arm, multicentre, phase 2 trial. Follicular lymphoma t 14;18 -negative is genetically a heterogeneous disease.

The molecular landscape and other distinctive features of primary cutaneous follicle center lymphoma. Genomic landscape of cutaneous follicular lymphomas reveals 2 subgroups with clinically predictive molecular features. Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphoma.

Mutations in early follicular lymphoma progenitors are associated with suppressed antigen presentation. The spectrum of MALT lymphoma at different sites: biological and therapeutic relevance.

Mutational landscape of marginal zone B-cell lymphomas of various origin: organotypic alterations and diagnostic potential for assignment of organ origin. Resistance of t 11;18 positive gastric mucosa-associated lymphoid tissue lymphoma to Helicobacter pylori eradication therapy.

Genome-wide DNA profiling of marginal zone lymphomas identifies subtype-specific lesions with an impact on the clinical outcome. Clinical and biological features of B-cell neoplasms with CDK6 translocations: an association with a subgroup of splenic marginal zone lymphomas displaying frequent CD5 expression, prolymphocytic cells, and TP53 abnormalities. KLF2 mutation is the most frequent somatic change in splenic marginal zone lymphoma and identifies a subset with distinct genotype.

High-throughput sequencing of nodal marginal zone lymphomas identifies recurrent BRAF mutations. Chronic lymphocytic leukemia and mantle cell lymphoma: crossroads of genetic and microenvironment interactions. Decoding the DNA methylome of mantle cell lymphoma in the light of the entire B cell lineage. A gene signature that distinguishes conventional and leukemic nonnodal mantle cell lymphoma helps predict outcome.

Genomic and epigenomic insights into the origin, pathogenesis, and clinical behavior of mantle cell lymphoma subtypes. Coding and noncoding drivers of mantle cell lymphoma identified through exome and genome sequencing. Genetic mutations and features of mantle cell lymphoma: a systematic review and meta-analysis. Genomic and transcriptomic profiling reveals distinct molecular subsets associated with outcomes in mantle cell lymphoma.

Aberrant somatic hypermutation of CCND1 generates non-coding drivers of mantle cell lymphomagenesis. Landscape of somatic mutations and clonal evolution in mantle cell lymphoma. TP53 mutations identify younger mantle cell lymphoma patients who do not benefit from intensive chemoimmunotherapy. High-dose cytarabine does not overcome the adverse prognostic value of CDKN2A and TP53 deletions in mantle cell lymphoma. KMT2D mutations and TP53 disruptions are poor prognostic biomarkers in mantle cell lymphoma receiving high-dose therapy: a FIL study.

Lenalidomide plus bendamustine-rituximab does not overcome the adverse impact of TP53 mutations in mantle cell lymphoma. Expression of TP53 is associated with the outcome of MCL independent of MIPI and Ki in trials of the European MCL Network. New molecular assay for the proliferation signature in mantle cell lymphoma applicable to formalin-fixed paraffin-embedded biopsies. The MCL35 gene expression proliferation assay predicts high-risk MCL patients in a Norwegian cohort of younger patients given intensive first line therapy.

Reproducibility of histologic prognostic parameters for mantle cell lymphoma: cytology, Ki67, p53 and SOX Metabolic reprogramming toward oxidative phosphorylation identifies a therapeutic target for mantle cell lymphoma.

Longitudinal single-cell profiling reveals molecular heterogeneity and tumor-immune evolution in refractory mantle cell lymphoma. Single-cell sequencing demonstrates complex resistance landscape in CLL and MCL treated with BTK and BCL2 inhibitors. Pharmacological and genomic profiling identifies NF-κB-targeted treatment strategies for mantle cell lymphoma.

Cyclin D dysregulation: an early and unifying pathogenic event in multiple myeloma. Gene expression profiling for molecular classification of multiple myeloma in newly diagnosed patients. Identification of novel mutational drivers reveals oncogene dependencies in multiple myeloma.

Bortezomib-based versus nonbortezomib-based induction treatment before autologous stem-cell transplantation in patients with previously untreated multiple myeloma: a meta-analysis of phase III randomized, controlled trials.

Evaluation of daratumumab for the treatment of multiple myeloma in patients with high-risk cytogenetic factors: a systematic review and meta-analysis.

Venetoclax or placebo in combination with bortezomib and dexamethasone in patients with relapsed or refractory multiple myeloma BELLINI : a randomised, double-blind, multicentre, phase 3 trial.

A validated gene expression model of high-risk multiple myeloma is defined by deregulated expression of genes mapping to chromosome 1. Whole-genome sequencing of multiple myeloma from diagnosis to plasma cell leukemia reveals genomic initiating events, evolution, and clonal tides.

Genome-wide somatic alterations in multiple myeloma reveal a superior outcome group. Whole-genome sequencing reveals progressive versus stable myeloma precursor conditions as two distinct entities. Copy number signatures predict chromothripsis and clinical outcomes in newly diagnosed multiple myeloma.

Genomic profiling of smoldering multiple myeloma identifies patients at a high risk of disease progression. The molecular make up of smoldering myeloma highlights the evolutionary pathways leading to multiple myeloma. International Myeloma Working Group risk stratification model for smoldering multiple myeloma SMM. Cytogenetic subclone formation and evolution in progressive smoldering multiple myeloma.

Genomic landscape of Waldenstrom macroglobulinemia and its impact on treatment strategies. Clonal architecture of CXCR4 WHIM-like mutations in Waldenström macroglobulinaemia. Pattern of somatic mutations in patients with Waldenström macroglobulinemia or IgM monoclonal gammopathy of undetermined significance. A matched case-control study comparing features, treatment and outcomes between patients with non-IgM lymphoplasmacytic lymphoma and Waldenström macroglobulinemia. Insights into the genomic landscape of MYD88 wild-type Waldenström macroglobulinemia.

Somatic mutations in MYD88 and CXCR4 are determinants of clinical presentation and overall survival in Waldenström macroglobulinemia. MYD88 wild-type Waldenstrom macroglobulinaemia: differential diagnosis, risk of histological transformation, and overall survival. MYD88 mutation status does not impact overall survival in Waldenström macroglobulinemia.

Bendamustine plus rituximab in newly-diagnosed Waldenström macroglobulinaemia patients. A study on behalf of the French Innovative Leukaemia Organization FILO.

Zanubrutinib for the treatment of MYD88 wild-type Waldenström macroglobulinemia: a substudy of the phase 3 ASPEN trial. Diagnostic next-generation sequencing frequently fails to detect MYD88LP in Waldenström macroglobulinemia.

Long-term follow-up of ibrutinib monotherapy in symptomatic, previously treated patients with Waldenström macroglobulinemia. Long-term follow-up of ibrutinib monotherapy in treatment-naive patients with Waldenstrom macroglobulinemia. A randomized phase 3 trial of zanubrutinib vs ibrutinib in symptomatic Waldenström macroglobulinemia: the ASPEN study.

CXCR4 mutation subtypes impact response and survival outcomes in patients with Waldenström macroglobulinaemia treated with ibrutinib. Molecular and genetic biomarkers implemented from next-generation sequencing provide treatment insights in clinical practice for Waldenström macroglobulinemia.

Bone marrow involvement and subclonal diversity impairs detection of mutated CXCR4 by diagnostic next-generation sequencing in Waldenström macroglobulinaemia. From Waldenström's macroglobulinemia to aggressive diffuse large B-cell lymphoma: a whole-exome analysis of abnormalities leading to transformation. Acquired mutations associated with ibrutinib resistance in Waldenström macroglobulinemia. TP53 mutations are associated with mutated MYD88 and CXCR4, and confer an adverse outcome in Waldenström macroglobulinaemia.

The double-hit signature identifies double-hit diffuse large B-cell lymphoma with genetic events cryptic to FISH. Determining cell-of-origin subtypes of diffuse large B-cell lymphoma using gene expression in formalin-fixed paraffin-embedded tissue. Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray.

Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma. Targeting B cell receptor signaling with ibrutinib in diffuse large B cell lymphoma.

Inhibition of B cell receptor signaling by ibrutinib in primary CNS lymphoma. Ibrutinib in PCNSL: the curious cases of clinical responses and aspergillosis. Randomized phase III trial of ibrutinib and rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone in non-germinal center B-cell diffuse large B-cell lymphoma. Effect of ibrutinib with R-CHOP chemotherapy in genetic subtypes of DLBCL. Gene-expression profiling of bortezomib added to standard chemoimmunotherapy for diffuse large B-cell lymphoma REMoDL-B : an open-label, randomised, phase 3 trial.

ROBUST: a phase III study of lenalidomide plus R-CHOP versus placebo plus R-CHOP in previously untreated patients with ABC-type diffuse large B-cell lymphoma. Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes.

Targeted sequencing in DLBCL, molecular subtypes, and outcomes: a Haematological Malignancy Research Network report. A probabilistic classification tool for genetic subtypes of diffuse large B cell lymphoma with therapeutic implications. Application of the LymphGen classification tool to clinically and genetically-characterised cases of diffuse large B cell lymphoma DLBCL.

Clinical and biological subtypes of B-cell lymphoma revealed by microenvironmental signatures. Prognostic significance of MYC rearrangement and translocation partner in diffuse large B-cell lymphoma: a study by the Lunenburg Lymphoma Biomarker Consortium. High-resolution architecture and partner genes of MYC rearrangements in lymphoma with DLBCL morphology. Robust detection of translocations in lymphoma FFPE samples using targeted locus capture-based sequencing.

Lymphomas with pseudo-double-hit BCL6-MYC translocations due to t 3;8 q27;q24 are associated with a germinal center immunophenotype, extranodal involvement, and frequent BCL2 translocations. The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms. Molecular high-grade B-cell lymphoma: defining a poor-risk group that requires different approaches to therapy. Characterization of the genetic landscape of high-grade B-cell lymphoma,—NOS - an LLMPP project.

Epstein-Barr virus status of sporadic Burkitt lymphoma is associated with patient age and mutational features. Genome-wide discovery of somatic coding and noncoding mutations in pediatric endemic and sporadic Burkitt lymphoma.

Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics. Genomic abnormalities of TP53 define distinct risk groups of paediatric B-cell non-Hodgkin lymphoma. Sequential inverse dysregulation of the RNA helicases DDX3X and DDX3Y facilitates MYC-driven lymphomagenesis. Genome-wide analysis of pediatric-type follicular lymphoma reveals low genetic complexity and recurrent alterations of TNFRSF14 gene. Recurrent loss of heterozygosity in 1p36 associated with TNFRSF14 mutations in IRF4 translocation negative pediatric follicular lymphomas.

Pediatric-type nodal follicular lymphoma: a biologically distinct lymphoma with frequent MAPK pathway mutations. A study of the mutational landscape of pediatric-type follicular lymphoma and pediatric nodal marginal zone lymphoma. Mutations of MAP2K1 are frequent in pediatric-type follicular lymphoma and result in ERK pathway activation. PNMZL and PTFL: morphological variants with a common molecular profile - a unifying hypothesis. Pediatric-type indolent B-cell lymphomas with overlapping clinical, pathologic, and genetic features.

Translocations activating IRF4 identify a subtype of germinal center-derived B-cell lymphoma affecting predominantly children and young adults. Patient age at diagnosis is associated with the molecular characteristics of diffuse large B-cell lymphoma. High resolution copy number analysis of IRF4 translocation-positive diffuse large B-cell and follicular lymphomas. Follicular lymphomas in children and young adults: a comparison of the pediatric variant with usual follicular lymphoma.

Diffuse large B-cell lymphomas in adults with aberrant coexpression of CD10, BCL6, and MUM1 are enriched in IRF4 rearrangements. A recurrent 11q aberration pattern characterizes a subset of MYC-negative high-grade B-cell lymphomas resembling Burkitt lymphoma. The mutational landscape of Burkitt-like lymphoma with 11q aberration is distinct from that of Burkitt lymphoma. Burkitt-like lymphoma with 11q aberration: a germinal center-derived lymphoma genetically unrelated to Burkitt lymphoma.

Partial trisomy 11, dup 11 q23q13 , as a defect characterizing lymphomas with Burkitt pathomorphology without MYC gene rearrangement. Deregulation of ETS1 and FLI1 contributes to the pathogenesis of diffuse large B-cell lymphoma. Single nucleotide polymorphism-arrays provide new insights in the pathogenesis of post-transplant diffuse large B-cell lymphoma. Molecular classification of primary mediastinal large B-cell lymphoma using routinely available tissue specimens.

Determination of molecular subtypes of diffuse large B-cell lymphoma using a reverse transcriptase multiplex ligation-dependent probe amplification classifier: a CALYM study. Integrative genomic analysis identifies key pathogenic mechanisms in primary mediastinal large B-cell lymphoma. Genomic analyses of PMBL reveal new drivers and mechanisms of sensitivity to PD-1 blockade.

Gene expression profiling of mediastinal gray zone lymphoma and its relationship to primary mediastinal B-cell lymphoma and classical Hodgkin lymphoma. Gray zone lymphoma: better treated like Hodgkin lymphoma or mediastinal large B-cell lymphoma?

A TaqMan low-density array to predict outcome in advanced Hodgkin's lymphoma using paraffin-embedded samples. Gene expression-based model using formalin-fixed paraffin-embedded biopsies predicts overall survival in advanced-stage classical Hodgkin lymphoma.

Gene expression-based outcome prediction in advanced stage classical Hodgkin lymphoma treated with BEACOPP. The gene gene expression-based assay does not predict interim PET scan results after ABVD in advanced stage classical Hodgkin lymphoma in the US Intergroup S trial. Prognostic model to predict post-autologous stem-cell transplantation outcomes in classical Hodgkin lymphoma.

A gene expression—based model predicts outcome in children with intermediate-risk classical Hodgkin lymphoma.

Validation of the RHL30 digital gene expression assay as a prognostic biomarker for relapsed Hodgkin lymphoma. Pervasive mutations of JAK-STAT pathway genes in classical Hodgkin lymphoma. Circulating tumor DNA reveals genetics, clonal evolution, and residual disease in classical Hodgkin lymphoma.

Genomic analyses of flow-sorted Hodgkin Reed-Sternberg cells reveal complementary mechanisms of immune evasion. Major histocompatibility complex class II and programmed death ligand 1 expression predict outcome after programmed death 1 blockade in classic Hodgkin lymphoma. Anaplastic large-cell lymphomas of T-cell and null-cell phenotype express cytotoxic molecules. ALK-positive lymphoma: a single disease with a broad spectrum of morphology.

Frequency and prognosis of associated malignancies in patients with lymphomatoid papulosis. Clinical, histologic, and molecular characteristics of anaplastic lymphoma kinase-positive primary cutaneous anaplastic large cell lymphoma.

Treatment options for paediatric anaplastic large cell lymphoma ALCL : current standard and beyond. Whole exome sequencing reveals NOTCH1 mutations in anaplastic large cell lymphoma and points to Notch both as a key pathway and a potential therapeutic target. Parrilla Castellar. ALK-negative anaplastic large cell lymphoma is a genetically heterogeneous disease with widely disparate clinical outcomes. DUSP22 and TP63 rearrangements predict outcome of ALK-negative anaplastic large cell lymphoma: a Danish cohort study.

Recurrent MSCEK mutations in ALK-negative anaplastic large cell lymphoma. Identification of high-risk DUSPrearranged ALK-negative anaplastic large cell lymphoma.

Discovery of recurrent t 6;7 p Molecular profiling reveals immunogenic cues in anaplastic large cell lymphomas with DUSP22 rearrangements. Chromosomal rearrangements of 6p Specificity of IRF4 translocations for primary cutaneous anaplastic large cell lymphoma: a multicenter study of skin biopsies. Assessment of diagnostic criteria between primary cutaneous anaplastic large-cell lymphoma and CDrich transformed mycosis fungoides; a study of 66 cases.

Genome-wide analysis reveals recurrent structural abnormalities of TP63 and other prelated genes in peripheral T-cell lymphomas. Co-occurring rearrangements of DUSP22 and TP63 define a rare genetic subset of ALK-negative anaplastic large cell lymphoma with inferior survival outcomes.

Identification of a new subclass of ALK-negative ALCL expressing aberrant levels of ERBB4 transcripts. Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic target. Convergent mutations and kinase fusions lead to oncogenic STAT3 activation in anaplastic large cell lymphoma. Targetable fusions of the FRK tyrosine kinase in ALK-negative anaplastic large cell lymphoma. STAT3 and TP53 mutations associate with poor prognosis in anaplastic large cell lymphoma.

A novel recurrent NPM1-TYK2 gene fusion in cutaneous CDpositive lymphoproliferative disorders. Next generation sequencing of breast implant-associated anaplastic large cell lymphomas reveals a novel STAT3-JAK2 fusion among other activating genetic alterations within the JAK-STAT pathway. Gene alterations in epigenetic modifiers and JAK-STAT signaling are frequent in breast implant—associated ALCL. Los-de Vries.

Chromosome 20 loss is characteristic of breast implant—associated anaplastic large cell lymphoma. Activating mutations in genes related to TCR signaling in angioimmunoblastic and other follicular helper T-cell—derived lymphomas.

Genetic drivers of oncogenic pathways in molecular subgroups of peripheral T-cell lymphoma. CDKN2A deletion is a frequent event associated with poor outcome in patients with peripheral T-cell lymphoma not otherwise specified PTCL-NOS. Detection of gene fusion transcripts in peripheral T-cell lymphoma using a multiplexed targeted sequencing assay.

Fusion transcripts FYN-TRAF3IP2 and KHDRBS1-LCK hijack T cell receptor signaling in peripheral T-cell lymphoma, not otherwise specified. Molecular heterogeneity in peripheral T-cell lymphoma, not otherwise specified revealed by comprehensive genetic profiling. Molecular diagnosis of T-cell lymphoma: a correlative study of PCR-based T-cell clonality assessment and targeted NGS. Early detection of T-cell lymphoma with T follicular helper phenotype by RHOA mutation analysis.

Nodal cytotoxic peripheral T-cell lymphoma occurs frequently in the clinical setting of immunodysregulation and is associated with recurrent epigenetic alterations.

Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence. High-risk clonal hematopoiesis as the origin of AITL and NPM1-mutated AML.

Clonal hematopoiesis in angioimmunoblastic T-cell lymphoma with divergent evolution to myeloid neoplasms. Treatment with 5-azacytidine induces a sustained response in patients with angioimmunoblastic T-cell lymphoma. Useful in certain circumstances to demonstrate monoclonality of B-cell lymphoproliferations to establish a diagnosis; mandatory in certain entities eg, pediatric-type FL. Prognostic and predictive. IGHV gene mutational status remains stable through the disease course and only needs to be performed once.

Determining BcR stereotypy and IGLV R mutation status for risk stratification; tracking of resistance mutations BTK , PLCG2 , and BCL2 ; supplemental Table 3 WGS for mutations, CNAs, SVs, and complex karyotype determination MRD testing using HTS to guide therapy decisions.

Prognostic and del 17p is predictive. FISH testing should be performed before each new course of therapy. TP53 sequencing should be performed before each new course of therapy unless already demonstrated. Useful to support the diagnosis on biopsy samples and in cases with uncommon presentations Follicular l ymphoma FL.

Consider if BCL2 IHC is negative. Further workup of BCL2 -R—negative FL shown in scenario 1B in Table 3. EZH2 mutation is predictive of response to EZH2 inhibition. Detection prompts considering a diagnosis of other entities; see scenarios 1 and 2 in Table 3 and supplemental Figure 3. Extranodal MZL of mucosa associated lymphoid tissue MALT lymphoma. MALT1 rearrangements are associated with lack of antibiotic response in H pylori —positive gastric MALT lymphoma MRD testing using HTS to guide treatment decisions WTS or targeted gene expression panel for proliferation and signatures of nnMCL vs cMCL.

Prognostic and guide management Multiple myeloma MM MM-NOS MM with recurrent genetic abnormality MM with CCND family translocation MM with MAF family translocation MM with NSD2 translocation MM with hyperdiploidy. t 11;14 predictive of response to venetoclax WGS for subtype assignment, risk stratification, and decision making MRD using HTS for decision making. Aids in the differential with small B-cell lymphomas; see scenario 2A in Table 3. Predictive of primary resistance to ibrutinib therapy Diffuse large B-cell lymphoma, NOS Germinal center B-cell subtype Activated B-cell subtype.

Prognostic for outcomes following R-CHOP GEP ; predictive of response to treatment at relapse High-grade B-cell lymphomas HGBCL HGBCL with MYC and BCL2 rearrangement HGBCL-DH- BCL2 HGBCL with MYC and BCL6 rearrangement HGBCL-DH- BCL6 HGBCL, NOS. Prognostic and predictive: HGBCL-DH- BCL2 has poor prognosis with R-CHOP and likely benefits from treatment intensification Rearrangement detection and MYC partner determination by HTS HTS analysis of HGBCL, NOS tumors to assign these tumors to definitive disease categories.

Useful in certain circumstances for diagnosis; see also scenario 3A in Table 3. Of note, pediatric-type FL and pediatric nodal MZL are not readily distinguishable by genomic features. Large B-cell lymphoma with 11q aberration. Large B-cell lymphoma with IRF4 rearrangement. FISH required for diagnosis of LBCL- IRF4 rearrangement Useful in certain circumstances for diagnosis; see also scenario 3A in Table 3.

WTS or targeted gene expression assays to determine T-cell repertoire and disease classification and detect driver fusions , WGS to detect CNAs and SVs ctDNA assays for disease monitoring.

Mutations and small indels in genes recurrently altered: HTS Various gene fusions: HTS or FISH. Useful in certain circumstances to establish clonality or to support the diagnosis of a specific entity. Mechanism of actionable alterations and how they could be targeted clinically is displayed in Figure 5. DUSPIRF4 6p DUSP22 -R defines a subtype of ALK- ALCL 2 ; see scenario 4E in Table 3.

Useful in certain circumstances to support the diagnosis; see scenario 4B in Table 3. DNMT3A hotspot mutation may be predictive of nonresponse to standard chemotherapy and associated with adverse prognosis Demonstration of genomic alterations useful in certain circumstances to establish clonality and support the diagnosis.

Adverse prognostic impact of higher mutation load, complex genomic imbalances, TP53 mutations, and Th2 molecular subgroup , , WGS, cytogenetics or array-based determination of SVs Gene expression—based subtyping or IHC surrogate for risk stratification and patient selection.

Useful in certain circumstances to support the diagnosis; see scenario 4C in Table 3. Useful in certain circumstances for prediction of response to PD1 inhibitors Integrated HTS and TME analysis for disease stratification and guiding treatment decisions , Disease follow-up and clonal evolution , We'll explore how Apple APIs can provide a solid foundation when creating apps for diverse audiences, and we'll share examples, challenges, and best SwiftUI now offers powerful tools to level up your layouts and arrange views for your app's interface.

We'll introduce you to the Grid container, which helps you create highly customizable, two-dimensional layouts, and show you how you can use the Layout protocol to build your own containers with Discover the latest additions to San Francisco — the system font for Apple platforms — and find out how they can provide more control and versatility when designing interfaces.

In addition to weights and optical sizes, San Francisco now supports three new width styles: Condensed, Compressed, and Discover how the SharedWithYou framework can augment your app's collaboration infrastructure. We'll show you how to send secure invitations to collaborative content and synchronize participant changes.

We'll also cover displaying content updates within the relevant conversation. For an Join us as we explore one of the core concepts in Swift concurrency: isolation of tasks and actors. We'll take you through Swift's approach to eliminating data races and its effect on app architecture. We'll also discuss the importance of atomicity in your code, share the nuances of Sendable Discover how you can reduce in-app stutters, first launch times, and new level load times when you generate your GPU binaries entirely at project build time with offline compilation.

We'll also show you how to improve total compile time and binary size for larger GPU programs using the "Optimize Join us as we explore the three parts of the development cycle that can help you optimize your Core Data and CloudKit implementation.

We'll show you how you can analyze your app's architecture and feature set to verify assumptions, explore changes in behavior after ingesting large data sets, and Learn how you can enhance your app with charts to communicate data with more clarity and appeal. We'll show you when to use charts, how to use them and how they work together in a chart design system. Discover MetalFX, a new API that provides platform optimized graphics effects for Metal applications.

With MetalFX Upscaling, your application can now render frames at a lower resolution, reducing rendering time, without compromising rendering quality. We'll also show you how and when to use its We'll take you through the latest updates to CloudKit Console and discover how you can explore and debug your containers on the web like never before.

Learn more about Act as iCloud, which helps you query records and view data from the perspective of another account. Discover how to share zones Go beyond the basics of string processing with Swift Regex. We'll share an overview of Regex and how it works, explore Foundation's rich data parsers and discover how to integrate your own, and delve into captures. We'll also provide best practices for matching strings and wielding Regex-powered Discover how you can support complex screen capture experiences for people using your app with ScreenCaptureKit.

We'll explore many of the advanced options you can incorporate including fine tuning content filters, frame metadata interpretation, window pickers, and more. At Apple, we believe that privacy is a fundamental human right, and protecting people's privacy is at the center of everything we do.

Discover how our engineering teams build privacy into all of our products and developer frameworks, and learn about the technologies and patterns you can adopt in EDR is Apple's High Dynamic Range representation and rendering pipeline. Explore how you can render HDR content using EDR in your app and unleash the dynamic range capabilities of HDR displays on iPhone and iPad. We'll show how you can take advantage of the native EDR APIs on iOS, provide best Discover how you can use the Background Assets framework to download large files directly from your CDN and improve the initial launch experience of your apps and games.

We'll show you how to schedule background downloads during initial app install, app updates, and periodically as someone uses Learn how you can surface great features from your app directly in Siri, Spotlight, and the Shortcuts app. We'll introduce you to App Shortcuts, provide best practices to help you evaluate features in your app that would work well as App Shortcuts, and take you through the process of creating one Learn how you can migrate to the latest App Store Server APIs and incorporate App Store Server Notifications.

We'll help you get started with these tools and provide best practices to make the most of managing in-app purchases on your server. Discover how you can sign JSON Web Tokens, verify Join us for an exciting update on Swift-DocC and learn how you can write and share documentation for your own projects. We'll explore improvements to Swift-DocC navigation and share how you can compile documentation for application targets and Objective-C code.

We'll also show you how to publish Discover distributed actors — an extension of Swift's actor model that simplifies development of distributed systems. We'll explore how distributed actor isolation and location transparency can help you avoid the accidental complexity of networking, serialization, and other transport concerns Learn how Core ML works with the CPU, GPU, and Neural Engine to power on-device, privacy-preserving machine learning experiences for your apps.

We'll explore the latest tools for understanding and maximizing the performance of your models. We'll also show you how to generate reports to easily Learn how you can bring Live Text support for still photos or paused video frames to your app. We'll share how you can easily enable text interactions, translation, data detection, and QR code scanning within any image view on iOS, iPadOS, or macOS. We'll also go over how to control interaction Ready for your Day 2 briefing?

Catch up on all the great sessions from Tuesday and get a sneak peek at the day ahead. Discover how you can help improve communication and collaboration in your app with Collaboration in Messages.

Learn how to tie a document to Messages conversations for simple sharing and discussion. Explore how you can keep everyone in the conversation up to date on the latest activity in the Explore how you can use Variable Color to make SF Symbols even more expressive. We'll show you how system-provided symbols use variable color and provide best practices and guidance for using it effectively. We'll also help you learn how to incorporate variable color into custom symbols using the RoomPlan can help your app quickly create simplified parametric 3D scans of a room.

Learn how you can use this API to easily add a room scanning experience. We'll show you how to adopt this API, explore the 3D parametric output, and share best practices to help your app get great results with Explore the latest features in Safari and WebKit and learn how you can make better and more powerful websites. We'll take you on a tour through the latest updates to HTML, CSS enhancements, Web Inspector tooling, Web APIs, and more.

Help make your Unity app or game an even better experience on Apple platforms. Learn how you can add Apple technologies directly to your projects with six plug-ins: Apple.

Core, Game Center, Game Controller, Accessibility, Core Haptics, and PHASE. We'll show you how you can add new gameplay Discover how you can use fast resource streaming in Metal 3 to quickly load assets. We'll show you how to use an asynchronous set-it-and-forget-it workflow in your app to take advantage of the speed of SSD storage and the throughput of Apple silicon's unified memory architecture.

We'll also HLS Content Steering dynamically steers clients to different servers based on load and redundancy. We'll take you through the latest updates to this framework and explore how you can introduce dynamically spawned CDNs to existing HLS clients with Pathway Cloning. We'll also share how you can Explore the latest updates to App Clips! Discover how we've made your App Clip even easier to build with improvements to the size limit as well as CloudKit and keychain usage.

We'll also show you how to use our validation tool to verify your App Clip and automate workflows for your advanced App Notarization works in tandem with macOS to help people safely download software for their Mac outside of the App Store.

Learn about the required transition from altool to notarytool and how the Xcode GUI can help you achieve better overall performance when notarizing your app. We'll also share Learn how you can bring desktop-class features to your iPad app. Explore updates to UINavigationBar that bring more discoverability and customizability to your app's features. Find out how the latest updates to UIKit can help make it easier and faster for people to explore content in your app It's time for a security upgrade: Learn how to add support for passkeys to create a quick and easy sign in experience for people, all while offering a radical increase to account security.

Passkeys are simple and strong credentials built to eliminate phishing attacks. We'll share how passkeys are Learn how you can use the Virtualization framework to quickly create virtual machines on your Mac. We'll show you how to create a virtual Mac and quickly test changes to your app in an isolated environment. We'll also explore how you can install and run full Linux distributions on Apple silicon, Learn how you can make your in-app purchase experience even better on iPhone, iPad, Mac, and Apple Watch.

We'll take you through enhancements to StoreKit 2 and App Store Server API, and explore improvements to App Store Server Notifications.

Discover how you can verify app purchases with App Learn how you can make your Unity games accessible on Apple platforms using our open source Accessibility plug-in. Follow along as we add support for assistive technologies like VoiceOver and Switch Control to a sample Unity game project.

We'll show you how you can automatically scale text with Learn how you can make your app more discoverable and increase app engagement when you use the App Intents framework. We'll take you through the powerful capabilities of this Swift framework, explore the differences between App Intents and SiriKit Intents, and show you how you can expose your Discover how the Nearby Interaction framework can help you easily integrate Ultra Wideband UWB into your apps and hardware accessories.

Learn how you can combine the visual-spatial power of ARKit with the radio sensitivity of the U1 chip to locate nearby stationary objects with precision. Discover how you can use AVFoundation to keep people focused on your media app's content — not your loading spinner. We'll show you how to support a responsive and fluid interface in your app, all while you create rich audiovisual compositions, load audiovisual assets, and prepare media Discover the latest updates to Create ML.

We'll share improvements to Create ML's evaluation tools that can help you understand how your custom models will perform on real-world data. Learn how you can check model performance on each type of image in your test data and identify problems within Discover the latest advances in Mac app development using AppKit.

We'll take you through the latest updates to SF Symbols, show you how you can elevate your interface with enhanced controls, and help you learn to coordinate your windows with Stage Manager. We'll also explore the latest sharing Meet Developer Mode — required on iOS 16, iPadOS 16, and watchOS 9 to install, run, and debug your apps during development. We'll show you how you to opt in to Developer Mode on your devices, and how to enable Developer Mode in your automation workflows.

Discover best practices and techniques to help craft magical AR experiences for iPhone and iPad. We'll provide guidance to help you determine if AR is a good fit for your experience, explore examples of great AR apps, and take you through key considerations when designing for augmented reality. Meet the Data Scanner in VisionKit: This framework combines AVCapture and Vision to enable live capture of machine-readable codes and text through a simple Swift API.

We'll show you how to control the types of content your app can capture by specifying barcode symbologies and language selection Discover how you can use iPhone as an external camera in any Mac app with Continuity Camera. Whether you're building video conferencing software or an experience that makes creative use of cameras, we'll show you how you can enhance your app with automatic camera switching.

We'll also explore how Discover the latest open source Swift package from Apple: Swift Async Algorithms. We'll explore algorithms from this package that you can use with AsyncSequence, including zip, merge, and throttle.

Follow along with us as we use these algorithms to build a great messaging app. Create ML makes it easy to build custom machine learning models for image classification, object detection, sound classification, hand pose classification, action classification, tabular data regression, and more.

And with the Create ML Components framework, you can further customize underlying WeatherKit offers valuable weather data for your apps and services to help people stay up to date on the latest conditions. Learn how to use Swift and REST APIs to access information about the current weather, day hourly forecasts for temperature, expected precipitation, wind reports, the UV Follow along as we demonstrate how you can use Object Capture and RealityKit to bring real-world objects into an augmented reality game.

We'll show you how to capture detailed items using the Object Capture framework, add them to a RealityKit project in Xcode, apply stylized shaders and Join us as we share the latest updates to SharePlay. We'll show you how you can start SharePlay sessions right from your app, take you through improvements to APIs to create richer experiences, and check out enhancements to GroupSessionMessenger. We'll also explore best practices for adding We'll take you through an overview of Xcode Cloud and how it connects with Xcode and App Store Connect.

We'll also explore the Xcode Cloud Usage Dashboard in App Store Harness the full potential of Apple silicon in your app with Metal 3. We'll introduce you to the latest features, improvements, and tooling.

We'll also explore how you can use advanced features and compiler tools to load resources faster, compile shader binaries at build time, process complex Discover the latest productivity and performance advancements in Xcode We'll introduce you to the fully redesigned SwiftUI canvas experience, explore enhancements to code completion and navigation, and take you through performance improvements we've made throughout the entire development Discover advanced desktop-class editing features that can help people accelerate their productivity in your app.

Learn how you can provide more interactions inline with your UI to help people quickly access editing features and make your iPadOS app feel right at home on macOS with Mac Catalyst Bring better notifications to your websites and web apps in Safari on macOS with Web Push.

We'll show you how you can remotely send notifications to people through the web standards-based combination of Push API, Notifications API, and Service Workers. It's a SwiftUI party — and you're invited! Join us as we share the latest updates and a glimpse into the future of UI framework design. Discover deep levels of customization, advanced techniques for layout, elegant strategies for sharing, and rock-solid structural approaches for designing an app Discover the latest updates and improvements to UIKit and learn how to build better iPadOS, iOS, and Mac Catalyst apps.

We'll take you through UI refinements, productivity updates, API enhancements, and more. We'll also help you explore improvements to performance, security, and privacy. CarPlay is a smarter, safer way to use your iPhone while you drive. Learn about the latest app types for CarPlay and discover how the CarPlay Simulator can help you develop and test apps without leaving your desk.

We'll also explore how navigation apps can connect with digital instrument clusters We're coming in loud and clear to help you bring walkie-talkie communication to your app — over! Discover how you can add prominent system UI to your Push to Talk app, enabling rapid communication with the tap of a button.

We'll introduce you to the PushToTalk framework and show you how to Learn how you can easily prototype and build apps with Swift Playgrounds. We'll show you how to create an app from a blank project, build its interface with SwiftUI, and use Swift Package Manager to add extra functionality from an open source package.

We'll also explore how you can debug issues Join us for an update on Swift. We'll take you through performance improvements, explore more secure and extensible Swift packages, and share advancements in Swift concurrency. We'll also introduce you to Swift Regex, better generics, and other tools built into the language to help you write more Discover how you can enhance and personalize your app using MusicKit. We'll take you through the latest additions to the MusicKit framework and explore how you can bring music content to your app through requests, metadata, and more.

Discover how you can customize app behaviors based on someone's currently enabled Focus. We'll show you how to use App Intents to define your app's Focus filters, act on changes from the system, and present your app's views in different ways.

We'll also explore how you can filter notifications Our widgets code-along returns as we adventure onto the watchOS and iOS Lock Screen. Learn about the latest improvements to WidgetKit that help power complex complications on watchOS and can help you create Lock Screen widgets for iPhone.

We'll show you how to incorporate the latest SwiftUI views Learn how you can optimize your app with the Swift Concurrency template in Instruments. We'll discuss common performance issues and show you how to use Instruments to find and resolve these problems. Learn how you can keep your UI responsive, maximize parallel performance, and analyze Swift We'll also share best practices for Find out how Bluetooth devices can send timely and relevant alerts to Apple Watch.

We'll show you how to take advantage of periodic data in complications, explore background peripheral discovery, and help you learn how to use characteristic monitoring in watchOS. We'll also share best practices Discover how you can create Shortcuts in your app with zero user setup. We'll show you how App Intents can help you present custom Shortcuts views, and explore how you can add support for parameterized phrases to allow people to quickly express their intent.

We'll also share how you can make your Explore enhancements to device management across Apple platforms. Improve device deployment workflows using the latest version of Apple Configurator for iPhone. Learn about identity technologies and MDM protocol updates for macOS, iOS and iPadOS. We'll also share an exciting change in how we The recipe for a great app begins with a clear and robust navigation structure. Join the SwiftUI team in our proverbial coding kitchen and learn how you can cook up a great experience for your app.

We'll introduce you to SwiftUI's navigation stack and split view features, show you how you can Simplify your app's mapping architecture by implementing the Apple Maps stack across MapKit, MapKit JS, and Apple Maps Server APIs. Learn how these APIs can reduce network calls and increase power efficiency, which can help improve the overall performance of your app. We'll show you how to use Explore the latest updates to SF Symbols, Apple's extensive library of iconography designed to integrate seamlessly with San Francisco, the system font for all Apple platforms.

Discover the latest additions to the SF Symbols library and new categories in the app. Learn about the new Automatic Learn how you can process strings more effectively when you take advantage of Swift Regex. Come for concise literals but stay for Regex builders — a new, declarative approach to string processing. We'll also explore the Unicode models in String and share how Swift Regex can make Unicode-correct Discover how you can easily connect Thunderbolt and USB accessories to iPad with DriverKit.

We'll show you how to convert your existing Mac drivers without any code changes, learn how to add real-time audio support with AudioDriverKit, and provide best practices and tips for developing drivers Say hello to Swift Charts — a flexible framework that helps you create charts entirely in SwiftUI that look and feel right at home on all Apple platforms. Discover how you can use compositional syntax to make informative, delightful, and accessible charts with less code.

We'll share the building It's time for your Day 1 report from Apple HQ. Check out all the exciting announcements and new technologies unveiled at WWDC22 — and learn more about what's coming tomorrow. Take a deeper dive into the latest tools, technologies, and advances across Apple platforms to help you create even better apps. The Apple Design Awards honors excellence in innovation, ingenuity, and technical achievement in app and game design. Watch along as we reveal and celebrate the winners.

The Apple Worldwide Developers Conference kicks off with exciting reveals, inspiration, and new opportunities. Join the worldwide developer community for an in-depth look at the future of Apple platforms, directly from Apple Park. It's time to say adieu to the week, and what a week it was! Tune in as we recap Friday and close out WWDC How do you approach creating apps for everyone? Learn from developers who are blind or deaf themselves as they discuss the process of making technology accessible.

Discover how their unique perspectives have sparked innovation at their companies and helped make their apps even more inclusive. Create SharePlay experiences that people can enjoy on the web and in your companion app. Learn how you can use the Group Activities framework in combination with a companion website to bring SharePlay to Safari, letting people connect with each other for enjoyable group interactions — even if We'll take Metal Performance Shaders Graph is a compute engine that helps you build, compile, and execute customized multidimensional graphs for linear algebra, machine learning, computer vision, and image processing.

Discover how MPSGraph can accelerate the popular TensorFlow platform through a Metal Learn how to easily build apps that share data between multiple iCloud users with NSPersistentCloudKitContainer.

Discover how to create informative experiences around shared data and learn about the CloudKit technologies that support these features in Core Data. To get the most out of this Join us for part two of our Code-Along series as we use SwiftUI to build a Mac app from start to finish.

The journey continues as we explore how our sample gardening app can adapt to a person's preferences and specific workflows. Learn how SwiftUI apps can automatically react to system settings, Discover how to keep your accounts, apps, and content protected. We'll explore the tools Apple has built to help developers keep their apps and systems safe and secure, and show you how to safeguard against attackers, bad actors and nefarious activity to help protect your ecosystem.

When you localize the text within your app, you can help make your app more accessible to a worldwide audience. Discover best practices for building your localization workflow, including how to write and format strings accurately, and learn how to prepare strings for localization in different Discover how Xcode can automatically track down infinite loops, unused code, and other issues before you even run your app.

CPU performance and network throughput rates keep improving, but the speed of light is one limit that isn't going any higher. Learn the APIs and best practices to maximize your app's responsiveness and efficiency by keeping network round-trip times low and minimizing the number of round trips Discover how you can deliver rich app experiences that include animation, sound, and haptics on iPhone.

Learn key concepts for designing multimodal experiences within the Core Haptics framework. We'll take you through our sample HapticRicochet app — where haptic and sound feedback is designed in Meet Safari redesigned and ready to help people explore the web. Discover how you can approach designing websites and apps for Safari, and learn how to incorporate the tab bar in your designs. We'll also take you through features like Live Text and accessibility best practices, explore the Learn about the basics of object lifetimes and ARC in Swift.

Dive deep into what language features make object lifetimes observable, consequences of relying on observed object lifetimes and some safe techniques to fix them.

Bring the power of machine learning directly to your apps with Core ML. Discover how you can take advantage of the CPU, GPU, and Neural Engine to provide maximum performance while remaining on device and protecting privacy. Explore MLShapedArray, which makes it easy to work with multi-dimensional Breakpoints can help you debug issues by allowing you to pause and inspect problems in the middle of a process. Discover the latest improvements to breakpoints in Xcode including column and unresolved breakpoints.

We'll also go over best practices for general breakpoints and LLDB tips and tricks. The web is changing, and the next major version of HTTP is here. Learn how ResearchKit and CareKit can work together to take the tedium out of paper surveys. Continue coding along with us and explore how you can make it easier than ever to schedule surveys for your study participants. You'll also learn advanced techniques for crafting evolving regiments in Discover how to use App Attest and DeviceCheck, Apple's powerful anti-fraud tools, created to safeguard your apps and content.

Unlock the secrets of deploying App Attest by incorporating it into your app to block unauthorized modifications of your app and content. We'll also show you how to use Discover how you can cross-reference Apple Music content within your app using the Apple Music API. We'll show you how to reference content across different geographical regions, map explicit to clean-equivalent content, fetch catalog and library relationships, and how to match content using the Learn how to present complex data through VoiceOver with the Accessibility Custom Content API.

Discover how you can deliver accessibility information in a concise form, and only when someone wants it. We'll show you how you can integrate AXCustomContent and help people who want VoiceOver enabled Join us for the last part of our code along as we put the finishing touches on our care pilot app. Explore how you can use advanced CareKit APIs to customize the appearance and behavior of task cards, Discover how you can take advantage of the latest networking technology and Apple hardware to create adaptive experiences for your content that best suit Discover the flexibility, versatility and power of Pixar's Universal Scene Description USD for your 3D workflows.

Learn how you can use the USD file format in your professional workflows for macOS: Scan 3D models of your real-world objects using Object Capture, utilize the potential of Code along with us and build a working care pilot app.

Explore best practices for onboarding and consent with ResearchKit, and find out how your app can require participants to sign consent documents by Discover how to achieve smooth screen updates on all Apple platforms that support dynamic display timing.

Learn techniques for pacing full-screen game updates on Adaptive Sync displays in macOS, and find out how Low Power Mode and other system states affect frame rate availability on ProMotion Discover how CloudKit Console can help you better interact with your containers.

We'll show you how to put the database app to work and define, modify, and deploy schema changes with confidence. You'll learn how to craft queries in the query builder and filter your records with ease. And we'll The Accelerate framework helps you make large-scale mathematical computations and image calculations that are optimized for high-performance, low-energy consumption. Explore the latest updates to Accelerate and its Basic Neural Network Subroutines library, including additional layers, activation Recurring leaderboards are a great way to encourage players to keep coming back to your game.

Code along with us as we take you through how to set up a recurring leaderboard, both within App Store Connect and in your game itself. For a refresher on the differences between recurring and classic Working with more complex Xcode projects? You've come to the right place. Discover how you can configure your project to build for multiple Apple platforms, filter content per-platform, create custom build rules and file dependencies, and more. We'll take you through multi-platform framework Code along with us as we use SwiftUI to build a Mac app from start to finish.

Discover four principles all great Mac apps have in common, and learn how to apply those principles in practice using SwiftUI. We'll show you how to create a powerful, flexible sidebar experience and transform lists to Where did the WWDC week go? We'll tell you: Check out everything you missed on Thursday and tune in for a quick preview of our final day at Dub Dub. This version includes American Sign Language ASL interpretation. Dan Harris is an Emmy Award-winning journalist and the co-anchor of ABC's weekend editions of Good Morning America.

After having a nationally-televised panic attack in , he found himself on a long and often bizarre journey that ended with him discovering mindfulness meditation. Dan will share App Analytics helps you maximize your opportunity on the App Store by providing privacy-friendly insights about your app. Learn about four new ways to grow your business, including information about custom product pages, in-app events, product page optimization, and new metrics about transactions Discover the principles for creating intuitive physical interactions between two or more devices, as demonstrated by Apple designers who worked on features for iPhone, HomePod mini, and AirTag.

Explore how you can apply these patterns to your own app when designing features for Apple platforms, Meet MailKit: the best way to build amazing experiences on top of Mail. MailKit enables apps to easily and securely interact with the Mail app for macOS. We'll deep dive into the MailKit API, and show you how to create extensions for composing messages, message actions, secure email, and content Discover how Vision can provide expert image recognition and analysis in your app to extract information from documents, recognize text in multiple languages, and identify barcodes.

We'll explore the latest updates to Text Recognition and Barcode Detection, show you how to bring all these tools The enhanced and new APIs in HomeKit enable smart home developers to integrate with the new Matter protocol in the most convenient way.

Tour the Matter protocol, and discover how to set up and manage Matter accessories on our platforms and within your smart home apps. Find out how you can use Apple TV's redesigned playback interface to build great media experiences in your apps. Learn how the latest interface helps people access relevant controls and information while maintaining focus on content.

We'll show you how you can adopt AVPlayerViewController and Discover how you can make key parts of your app available for someone at exactly the right moment — without them ever needing to open it. Learn how to craft and donate intents to the system, helping you surface relevant and contextual information about your app in Siri, Focus, Shortcuts, the Find out how you can use the FileProvider framework to build a comprehensive cloud sync solution. We'll show you how to approach building a file provider extension, and explore how you can effortlessly integrate your extension with file system features such as safe save, disk space management, Great customer support is critical to running a successful business on the App Store.

Discover how you can provide a frictionless support experience to customers who make in-app purchases, including APIs that make it easy for customers to manage or cancel their auto-renewable subscription, or Discover how Core Data is adopting the new concurrency capabilities of Swift 5.

We'll show you how to update Core Data in your apps to work with concurrency, and detail the many other improvements throughout the framework that make Testing is a crucial part of building a great app: Great tests can help you track down important issues before release, improve your workflow, and provide a quality experience upon release.

For issues that can't be immediately resolved, however, XCTest can help provide better context around those Whether you're curating packages for your team, for education purposes, or to share with other developers, Swift Package Collections can help you discover, explore and import new packages into your project. Discover improvements in the Swift Package workflow using Collections, and learn how you Discover how to distribute your apps directly to App Store Connect and all the distribution methods supported in Xcode.

Explore how to automate distribution for your apps, and learn about improvements to the distribution workflow like cloud signing, app record creation, and build number management. Go beyond basic streaming and interaction and discover how you can build advanced SharePlay experiences using the full power of the Group Activities framework.

We'll show you how to adapt a simple drawing app into a real-time shared canvas, explore APIs like GroupSessionMessenger — which helps Discover the Apps and Books Management API and explore how you can assign an organization's owned apps and books to managed users and devices. Learn about the latest API improvements and find out how you can subscribe to and receive notifications around asset counts, assignments, and registered In a managed device environment, you often need to control the pace of software updates while you test the latest operating systems within your company or education institution.

Discover the tools you have at your disposal to defer, deploy, and enforce software updates. Optimize your high-end games for Apple GPUs: We'll show you how you can use our rendering and debugging tools to eliminate performance issues and make your games great on Apple platforms. Learn from our experiences working with developers at Larian Studios and 4A Games as we help them optimize Discover how to more easily build and extend your render pipelines using Dynamic Libraries and Function Pointers.

We'll also show you Advances in Apple Watch give you more ways to communicate to and from your app, and new audiences to consider. Learn what strategies are available for data communication and how to choose the right tool for the job. Compare and contrast the benefits of using technologies such as iCloud Keychain, It's never been easier to test your CloudKit containers. We'll introduce you to cktool, a command-line utility that makes quick work of CloudKit configuration, and learn about the new schema language that allows you to rapidly prototype and evolve containers.

We'll also show you how to combine Never again miss anyone's great moment in your game or app. Learn about ReplayKit's latest update — clips screen recording — which provides your app with a rolling buffer of past video and audio samples.

When memorable moments happen, discover how you can record and save it for people, and find Explore how you can render HDR content using EDR in your app and unleash the dynamic range capabilities of your HDR display including Apple's internal displays and Pro Display XDR. We'll show you how game and pro app iPhone and iPad support numerous input modes for those with motor impairments, including touch interaction modification, Switch Control, and Full Keyboard Access.

We'll explore how people can interact with their devices solely through keyboard input, working through a real-life example to PHPicker is the simplest and most secure way to integrate the Photos library into your app — and it's getting even better.

Learn how to handle ordered selection of images in your app, as well as pre-selecting assets any time the picker is shown. And for apps that need to integrate more deeply Develop in JavaScript, WebGL, or WebAssembly? Learn how the latest updates to Safari and WebKit — including language changes to class syntax — can help simplify your development process, enhance performance, and improve security.

We'll explore several web APIs that can help provide better The ClassKit framework can help surface educational activities within your app to teachers using the Schoolwork app. Discover how you can provide teachers with greater insights into student learning by adopting the latest file-based API to report student progress data within your app. Discover how you can understand and diagnose memory performance problems with Xcode. We'll take you through the latest updates to Xcode's tools, explore Metrics, check out the memgraph collection feature in XCTest, and learn how to catch regressions using a Performance XCTest.

Your app can take full advantage of the powerful camera systems on iPhone by using the AVCapture APIs. Learn how to choose the most appropriate photo or video formats for your use cases while balancing the trade-offs between photo quality and delivery speed. Discover some powerful new algorithms Test repetitions can help you debug even the most unreliable code. Discover how you can use the maximum repetitions, until failure, and retry on failure testing modes within test plans, Xcode, and xcodebuild to track down bugs and crashers and make your app more stable for everyone.

To get the Web Inspector provides the tools for you to understand and debug your web pages on macOS, iOS, and iPadOS. We'll take you through the latest features and improvements to Web Inspector, including a new overlay for inspecting CSS Grid containers on your pages, even more configurable breakpoints to Learn how to localize your SwiftUI app and make it available to a global audience.

Explore how you can localize strings in SwiftUI, including those with styles and formatting. We'll demonstrate how you can save time by having SwiftUI automatically handle tasks such as layout and keyboard Dive into the details of Swift concurrency and discover how Swift provides greater safety from data races and thread explosion while simultaneously improving performance.

We'll explore how Swift tasks differ from Grand Central Dispatch, how the new cooperative threading model works, and how to With device input — as with all things in life — where you put focus matters. Discover how you can move focus in your app with SwiftUI, programmatically dismiss the keyboard, and build large navigation targets from small views.

Together, these APIs can help you simplify your app's interface and Learn how you can interact with devices in UI Tests in Xcode Discover newly-automatable input methods including iPadOS pointer, watchOS Digital Crown, and enhanced macOS trackpad scrolling APIs. Build the next generation of augmented reality apps with ARKit 5. Explore how you can use Location Anchors in additional regions and more easily onboard people into your location-based AR experience.

Learn more about Face Tracking and Motion Capture. And discover best practices for placing your Discover how you can author immersive tutorials from scratch with DocC. We'll demonstrate how you can bring together rich instructions, example code, and images through the DocC syntax to showcase your Swift framework in action. And we'll go over how to create progressive training that can Discover how you can measure your ad campaigns in apps and on the web without compromising privacy.

We'll introduce you to Private Click Measurement and explore SKAdNetwork, which provides you with a more secure, private, and useful way to measure your app installs. Discover how you can track down hangs and delays in your app. We'll show you tools and methods to discover hangs and their causes, learn about anti-patterns that can lead to hangs, explore best practices for eliminating hangs like GCD, and provide guidance on when you should consider asynchronous Learn how you can design your app to support SharePlay experiences.

We'll show you how you can bring people together in your app using the Group Activities framework, and adapt your design to focus on group-first content sharing. And we'll explore ideas and iteration around apps and functions you Discover the latest updates to AVFoundation, Apple's framework for inspecting, playing, and authoring audiovisual presentations.

We'll explore how you can use AVFoundation to query attributes of audiovisual assets, further customize your custom video compositions with timed metadata, and author Explore the foundations of great widgets by keeping them relevant and customizable.

Learn how to keep widgets up to date with timeline entries and TimelineReloadPolicies. Discover how to adapt your widget to different presentation environments and physical location.

And lastly, find out how to Discover how to optimize your image processing app for Apple silicon. Explore how to take advantage of Metal render command encoders, tile shading, unified memory architecture, and memoryless attachments. We'll show you how to use Apple's unique tile based deferred renderer architecture to create Well hello, Wednesday!

Time to catch up on Day 3 at WWDC and find out what's coming to a Thursday near you. Discover how Apple creates products that work well for everyone. Learn from a few of the engineers and designers who helped build Apple Watch as they share stories that highlight our approach to accessible design, constant iteration, and community engagement.

This version includes American Sign Learn to use the Instruments Network template to record and analyze your app's HTTP traffic. We'll show you how to explore and visualize the behavior of sessions, tasks, and individual HTTP requests to ensure data is transmitted efficiently and respects people's privacy. Explore how Xcode can help you take your Metal debugging, profiling and asset creation workflows to the next level.

Discover the latest tools for ray tracing and GPU profiling, and learn about Metal Debugger workflows. We'll also show you how to use the Texture Converter tool, which supports all Learn how Xcode Organizer makes it easier and faster to triage and fix crashes. We'll explore how you can get access to crash information and feedback from your TestFlight testers just moments after they occur.

And we'll show you how to analyze crashes, view metrics, and even share crash Peek behind the curtain into the core tenets of SwiftUI philosophy: Identity, Lifetime, and Dependencies. Find out about common patterns, learn the principles that drive the framework, and discover how you can use them to guarantee correctness and performance for your app. Discover how you can incorporate SF Symbols into your SwiftUI app. We'll explore basic techniques for presenting symbols, customizing their size, and showing different variants.

We'll also take you through the latest updates to symbol colorization and help you pick the right tool for your app's Discover how you can use HLS playlist tags and the Steering Manifest format with your content to help dynamically update CDN redundancy policies tuned for each viewer. Learn how to load balance, set failover, and more. Discover the latest updates to managing in-app purchases on your server.

Explore how you can use servers to track status changes, handle refunds, and manage subscriber status. Learn about App Store server APIs around status and in-app purchase transactions, and find out how App Store server Go beyond the basics to deliver an exceptional accessibility experience. Learn how to use the new SwiftUI Previews in Xcode to explore the latest accessibility APIs and create fantastic, accessible apps for everyone. Find out how you can customize the automatic accessibility built into SwiftUI to Build consistently smooth scrolling list and collection views: Explore the lifecycle of a cell and learn how to apply that knowledge to eliminate rough scrolling and missed frames.

We'll also show you how to improve your overall scrolling experience and avoid costly hitches, with optimized image When you support ProRAW in your app, you can help photographers easily capture and edit images by combining standard RAW information with Apple's advanced computational photography techniques.

We'll take you through an overview of the format, including the look and feel of ProRAW images, quality Discover how you can help people watch or listen to content all in sync with SharePlay and the Group Activities framework. We'll show you how to adapt a media app into a synchronized, SharePlay-enabled experience for multiple people.

Learn how to add Group Activities to your app, explore the Discover how you can iterate upon your interfaces even more quickly when building your apps. Learn how you can modernize your UI with the latest button styles and table view cell content configurations, both of which give you greater control directly inside of Interface Builder. We'll show you Discover how you can use the Apple Music API to fetch music catalog metadata for your app.

Explore the latest updates to the API as well as some advanced techniques for shaping your requests and highlighting the right metadata for a project. To get the most out of this session, we recommend some Discover how you can achieve maximum performance and insightful debugging with your app. Symbolication is at the center of tools such as Instruments and LLDB to help bridge the layers between your application's runtime and your source code.

Learn how this process works and the steps you can take With Create ML, your app's ability to understand the expressiveness of the human hand has never been easier.

Discover how you can build off the support for Hand Pose Detection in Vision and train custom Hand Pose and Hand Action classifiers using the Create ML app and framework. Learn how simple Build a workout app from scratch using SwiftUI and HealthKit during this code along.

Learn how to support the Always On state using timelines to update workout metrics. Follow best design practices for workout apps. Discover simple ways to bring your Object Capture assets to AR Quick Look while optimizing for visual quality and file size.

Explore ways you can integrate AR Quick Look and Object Capture to help create entirely new experiences. To get the most out of this session, we recommend first watching Learn more about the evolution of notifications on Apple platforms. We'll explore how you can help people manage notifications within your app, including how you can craft meaningful moments with interruption levels and Time Sensitive notifications. And we'll introduce you to communication Explore the latest updates to WKWebView.

We'll show you how to use APIs to manipulate web content without JavaScript, explore delegates that can help with WebRTC and Downloads, and share how you can easily create a richer web experience within your app. Discover how your app can train Core ML models fully on device with the Create ML framework, enabling adaptive and customized app experiences, all while preserving data privacy. We'll explore the types of models that can be created on-the-fly for image-based tasks like Style Transfer and Image Explore the latest enhancements to code review and pull requests in Xcode.

Learn more about diff display preferences, commit selectors, changes navigator, and pull request workflows. We'll show you how you can collaborate with your team and find regressions by connecting your code review and PR Apple Configurator is now more capable than ever.

Whether you're provisioning iOS, iPadOS, and tvOS devices in your organization or servicing existing macOS devices, learn how Apple Configurator can help with key workflows. And, coming to iPhone in iOS 15, discover how you can bring Automated Tour the latest updates to the SF Symbols app — our interactive library for iconography.

Learn how you can use the library to design accessible and inclusive apps that look incredible: We'll take you through changes to the app and symbols search, explore previewing and custom symbol management, Learn how you can link your app to Quick Note and help people quickly connect your content to their notes — and their notes to your content.

Discover how Quick Note recognizes and links to app content through NSUserActivity, and find out how you can adopt this API in your app. We'll take you

A federal appeals court struck a major blow against the Consumer Financial Protection Bureau with a finding that its funding mechanism is unconstitutional. The decision is likely to be challenged, setting up a major fight for the future of the top U. consumer-finance watchdog. As set up under the Dodd-Frank Act, the CFPB is funded by the Federal Reserve rather than congressional appropriations. But Republicans have chafed at what they view as anti-business practices and a lack of oversight.

The structure has been the target of legal challenges before. Democratic Sen. Elizabeth Warren, who oversaw the CFPB's creation , responded to the ruling on Twitter, writing that "extreme right-wing judges are throwing into question every rule the CFPB enforces to protect consumers and businesses alike.

Republican Sen. Cynthia Lummis, meanwhile, said the CFPB "needs the same Congressional oversight as every other government agency. The CFPB is expected to challenge the ruling, though it has yet to confirm that. To that point, the CFPB issued new guidance to credit-reporting agencies Thursday about omitting what it called "junk data" from credit reports. The CFPB has faced several challenges to its existence over its 11 years in business.

In , the Supreme Court ruled that restrictions on when its leader can be removed were unconstitutional, but rejected a plea to strike down the agency as a whole. The most significant fear from progressive lawmakers and consumer groups is that the CFPB could see its resources chopped if left to the whims of Congress.

Public Interest Research Group. The new court decision comes as the CFPB, under Biden-appointed director Rohit Chopra , has taken a more aggressive stance toward the financial industry than his Trump administration predecessors. Chopra has also promised scrutiny over the way large technology companies are expanding into financial services.

But the agency is also taking up initiatives with fintech industry support, including finally setting up open-banking rules to guide data-sharing between financial institutions and tech companies. What the ruling means for the fintech industry remains to be seen.

While regulators and companies can occasionally come into conflict, the agencies also serve an important role in providing rules of the road and certainty for business models. His decisions on major cryptocurrency cases have quoted "The Big Lebowski," "SNL," and "Dr. The ways Zia Faruqui right has weighed on cases that have come before him can give lawyers clues as to what legal frameworks will pass muster.

Veronica Irwin vronirwin is a San Francisco-based reporter at Protocol covering fintech. Previously she was at the San Francisco Examiner, covering tech from a hyper-local angle. Before that, her byline was featured in SF Weekly, The Nation, Techworker, Ms. Magazine and The Frisc.

One hundred percent electronic. The author is Magistrate Judge Zia Faruqui. His rulings have made smart references to "The Big Lebowski," "Dr. Strangelove," and "SNL" parodies of the McLaughlin Group. Rather, before taking the judge position Faruqui was one of a group of prosecutors in the U. There, Faruqui prosecuted cases that involved terrorism, child pornography, and weapons proliferation. But the ways Faruqui has weighed on cases that have come before him can give lawyers clues as to what legal frameworks will pass muster.

Crypto lawyers have drawn on his prior decisions in the context of the Tornado Cash sanctions, for example. Faruqui spoke with Protocol about the power of his position, and what people in crypto should understand about the law. There was another prosecutor, Christopher Brown — you know, the other Chris Brown — and he had taken an interest in this when we were both working on financial crime in the Washington, D.

Our U. attorney at the time, Jessie Liu, had this idea of using financial investigations in a way that was not limited to just white collar crime, or even narcotics cases, but also for cyber investigations, to national security investigations, and in civil cases. A lot of what we were investigating was related to following the money and so she wanted us to be this multidisciplinary unit.

But I have to say, we started with the goal of wanting to make T-shirts, and we never did that while I was there. Your decisions have also gotten a lot of attention.

We're public servants! And in order for the public to have faith and trust us, they need to understand what it is that we're doing and what we're saying. Humor is one way, not using a lot of legalese is another way. But I think there are many judges who are trying to make the judiciary more accessible, and so people can see the work that we're doing and understand what we're doing and then make their own opinions about if it's right or wrong.

But at least, if it's understandable, then there's still some trust in the framework even if you don't agree with how our decisions are stated. We are ambassadors for the judiciary to the people in our courtroom — it's a very frightening proposition being in court if you've been federally charged, and people have perceptions of what they think can happen there in terms of fairness or unfairness. But then it goes far beyond that. I do a lot of work with the Administrative Office of the Courts, our central body doing civic education and outreach to high schools, because I want college and high school students and law students to have an experience where they get a chance to talk to a judge.

So my goal is certainly not just getting to one segment of the population, but it's making decisions accessible to whoever's interested in reading them. What has it felt like for you switching from that prosecutor role to magistrate judge? Lawyers are trying to take different frameworks from one topic and apply them to another, and then convince you that that is or is not appropriate. Being a judge is very different because you're evaluating what the parties present to you as the applicable legal frameworks, and deciding how new, groundbreaking technology fits into legal frameworks that were written 10 or 15 years ago.

But that's not really a place where judges get involved in saying how it ought to be regulated. There was, famously, a judge in Florida that said cryptocurrency was not money because you couldn't put it underneath your bed, and that's what money is: something that is tangible.

So different people are going to have different decisions. And that's not just true for crypto, but also other areas of the law. Your best-known crypto decisions strongly assert that crypto is traceable. One way people try to make it less traceable is with mixers, and Tornado Cash was sanctioned by OFAC not too long ago. Do you think the legal reasoning was sound enough for similar sanctions to be applied to other mixers, or decentralized exchanges?

I don't know. I think there's been some discussion that people may litigate some of these things, so I can't comment, because those frequently do come to our courthouse. And I think there are certainly people opining on that, yes and no.

So much of what judges do is that we rely on the parties that are before us to tell us what's right and what's wrong. And then, you know, obviously, they'll have different views, and we make a decision based on what people say in front of us. Are you aware that some legal analysis of the Tornado Cash sanctions references your recent decision in a cryptocurrency sanctions case? That's what good lawyers will always do. Even legislators might look at that as they try to think about where the gaps are.

As a prosecutor I had a case where we sued three Chinese banks to give us their bank records, and it had never been done before.

Afterwards, Congress passed a new law, using the decisions from judges in this court and the D. circuit court, the court above us. So I'm sure people look at prior decisions and try to apply them in the ways that they want to.

Are there any misconceptions about how the law applies to crypto, or how your decisions should be interpreted, that you wish you could get across? One misconception is that the judges can't understand this technology — we can.

People have these views in two extremes. The lawyer's fundamental job is to take super complex and technical things and boil them down to very easily digestible arguments for a judge, for a jury, or whoever it might be. The financial technology transformation is driving competition, creating consumer choice, and shaping the future of finance. Hear from seven fintech leaders who are reshaping the future of finance, and join the inaugural Financial Technology Association Fintech Summit to learn more.

Financial technology is breaking down barriers to financial services and delivering value to consumers, small businesses, and the economy. Fintech puts American consumers at the center of their finances and helps them manage their money responsibly. From payment apps to budgeting and investing tools and alternative credit options, fintech makes it easier for consumers to pay for their purchases and build better financial habits.

Fintech also arms small businesses with the financial tools for success, including low-cost banking services, digital accounting services, and expanded access to capital.

We advocate for modernized financial policies and regulations that allow fintech innovation to drive competition in the economy and expand consumer choice. Spots are still available for this hybrid event, and you can RSVP here to save your seat. Join us as we discuss how to shape the future of finance.

In its broadest sense, Open Banking has created a secure and connected ecosystem that has led to an explosion of new and innovative solutions that benefit the customer, rapidly revolutionizing not just the banking industry but the way all companies do business. Target benefits are delivered through speed, transparency, and security, and their impact can be seen across a diverse range of use cases.

Sharing financial data across providers can enable a customer individual or business to have real-time access to multiple bank accounts across multiple institutions all in one platform, saving time and helping consumers get a more accurate picture of their own finances before taking on debt, providing a more reliable indication than most lending guidelines currently do.

Companies can also create carefully refined marketing profiles and therefore, finely tune their services to the specific need. Open Banking platforms like Klarna Kosma also provide a unique opportunity for businesses to overlay additional tools that add real value for users and deepen their customer relationships. The increased transparency brought about by Open Banking brings a vast array of additional benefits, such as helping fraud detection companies better monitor customer accounts and identify problems much earlier.

The list of new value-add solutions continues to grow. The speed of business has never been faster than it is today. For small business owners, time is at a premium as they are wearing multiple hats every day. Macroeconomic challenges like inflation and supply chain issues are making successful money and cash flow management even more challenging. This presents a tremendous opportunity that innovation in fintech can solve by speeding up money movement, increasing access to capital, and making it easier to manage business operations in a central place.

Fintech offers innovative products and services where outdated practices and processes offer limited options. For example, fintech is enabling increased access to capital for business owners from diverse and varying backgrounds by leveraging alternative data to evaluate creditworthiness and risk models.

Potential prognostic associations have been reported for TP53 mutations, and this could eventually improve risk stratification. At its core, it is about putting consumers in control of their own data and allowing them to use it to get a better deal. Take advantage of the all-screen design of the new iPad Pro by building your app with the iOS Aberrant somatic hypermutation of CCND1 generates non-coding drivers of mantle cell lymphomagenesis. Mutations of FGFR3 black and PRKD2 gray are common in NSD2, whereas mutations of CCND1 black and IRF4 gray are common in CCND.

Categories:

• Forex
• Forex Brokers
• Binary Options online
• Forex Bitcoin
• Binary Options